(80) Marschall, A.L.J., Zhang, C., Frenzel, A., Schirrmann, T., Hust, M., Perez, F. and Dübel, S (2014). Generating recombinant antibodies to the complete human proteome. (93) Rasetti-Escargueil, C., Avril, A., Tierney, R., Bak, N., Miethe, S., Chahboun, S., Mazuet, C., Popoff, M., Thullier, P., Hust, M., Pelat, T. and Sesardic, D. (2015). It's current labs are located in the Biocentre and the BRICS. So-called antibody gene libraries contribute to this. (39) Schirrmann, T., Menzel, C., Hust, M., Prilop, J., Jostock, T. and Dübel, S. (2010). ➜ Clusters of Excellence: In the Excellence Strategy of the Federal Government and States in 2018, TU Braunschweig was successful with two applications. Viruses 10: 147, (125) Sadana, P., Geyer, R., Pezoldt, J., Helmsing, S., Huehn, J., Hust, M., Dersch, P. and Scrima, A. They have been working in the Corona Antibody Team (CORAT) for several months. Der Professor für Biotechnologie an der Technischen Universität Braunschweig ist selbst schon Opfer einer Zecke geworden, die ihn infizierte. Prof. Dr. Michael Hust Technische Universität Braunschweig Institut für Biochemie, Biotechnologie und Bioinformatik Abteilung Biotechnologie Spielmannstraße 7 38106 Braunschweig Tel. Normally, the corresponding approval procedure takes about one and a half years or more. BIOSpektrum (Springer-Verlag, Heidelberg). (AA), Dipl.-Ing. Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System. (124) Russo, G., Theisen, U., Fahr, W., Helmsing, S., Hust, M., Köster R.W. (19) Pelat, T., Hust, M., Laffly. (85) Miethe, S., Pelat, T., Avril, A., Popoff, M., Molgo, J., Rasetti‑Escargueil, C., Fontayne, A., Korkeala, H., Thullier, P., Sesardic, D. and Hust, M. (2014). Expression rekombinanter Proteinpharmazeutika. Obtention and engineering of non-human primate (NHP) antibodies for therapeutics. Pflegedienst Pflege to Hus Herzlich Willkommen. B., Hust, M. and Zielonka S. (in press). (2014). (92) Miethe, S., Rasetti-Escargueil, C., Avril, A., Liu, Y., Chahboun, S., Korkeala, H., Mazuet, C., Popoff, M.-R., Pelat, T., Thullier. and Reinard, T. (2002). Human Anti-Lipopolysaccharid (LPS) antibodies against Legionella with high species specificity. But what is the best way to look for it? and Hust, M.. (120) Unkauf, T., Hust, M. and Frenzel, A. (49) Schirrmann, T. and Hust, M. (2010). In: Antibody engineering Vol 2, Ed: Kontermann, R. and Dübel, S.. (44) Breitling, F., Broders, O., Helmsing, S., Hust, M. and Dübel, S. (2010). (62) Frenzel, A., Fröde, D., Meyer, T., Schirrmann, T. and Hust, M. (2012). (17) Hust, M., Jostock, T., Menzel, C., Voedisch, B., Mohr, A., Brenneis, M., Kirsch, M.I., Meier, D. and Dübel, S. (2007). Originally known as Collegium Carolinum, it was established in 1745 as a mid-way institution between high school and university, teaching technical and mathematical subjects as well as fine arts and humanities. Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV). Recombinant VHHA6 cDNA was cloned into the pCMX expression vector (contributed by M. Hust, TU Braunschweig), which encodes an optimized human IgG1 Fc domain. Initiiert wurde das CORAT Konsortium von Professor Stefan Dübel und Professor Michael Hust vom Institut für Biochemie, Biotechnologie und Bioinformatik der TU Braunschweig. (126) Burke, C.W., Froude, J.W., Miethe, S., Hülseweh, B., Hust, M. and Glass, P.J. A total of 20 µg CMX VHH-Fc plasmid DNA and 60 µL PEI (1 mg/mL) were used to transiently transfect 5 × 10 6 HEK293T cells. (115) Rasetti-Escargueil , C., Avril, A., Miethe, S., Mazuet, C., Derman, Y., Selby, K., Thullier, P., Pelat, T., Urbain, R., Fontayne, A., Korkeala, H., Sesardic, D., Hust, M. and Popoff, M.R. Single chain antibodies as tools to study TGF-β regulated SMAD proteins in proximity ligation-based pharmacological screens. (97) Connor, D.O., Zantow, J., Hust, M., Bier, F.F. Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody. (10) Hust, M., Toleikis, L. and Dübel, S. (2005). m.hust@tu-bs.de. (6)Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany. Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity. Immune libraries from non-human primates (NHP). In: Handbook of therapeutic antibodies, 2nd ed., Ed. (12) Konthur, Z., Hust, M. and Dübel, S. (2005). Production of recombinant antibody fragments in. On the influence of vector design on antibody phage display. (2012). Department of Biotechnology Pyruvate dehydrogenase complex - enzyme 2, a new target for. First lab space was located in the GBF (National Research Centre for Biotechnology, Braunschweig, now: Helmholtz Centre for Infection Reserach). Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. Ihr Ziel ist es, einen universellen Impfstoff gegen von … However, since SARS-CoV-2 is a novel virus, many people have not yet developed antibodies against it. Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model. (102) Kuhn, P., Fühner, V., Moreira, G.M.S.G., Frenzel, A., Miethe, S. and Hust, M. (2016). (132) Ramli, R.S., Moreira, G.M.S.G., Zantow, J., Goris, M.G.A., Nguyen, V.K., Novoselova, N., Pessler, F. and Hust, M. (2019). Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor. Using the antibody gene libraries, the team is now testing which antibodies bind to the protein envelope of the corona virus and thus prevent it from intruding into other cells. Phage display-derived human antibodies in clinical development and therapy. Trends in Biotechnology 22, 8-14, (4) Meyer, T., Hust, M., Marquardt, J., Krumbein, W.E. There, SARS-CoV-2 viruses are used to test whether the antibodies can block these viruses. Production systems for recombinant antibodies. Selection of recombinant antibodies from antibody gene libraries. © Copyright 2015 - 2020 TU Braunschweig | Blogs, Insights into the work of the Corona Antibody Team, Institute of Biochemistry, Biotechnology and Bioinformatics, Institute for Biochemistry, Biotechnology and Bioinformatics, Collaborative Research Centres, Research Groups and Priority Programmes. (122) Moreira, G.M.S.G., Fühner, V. and Hust, M. (2018). (69) Miethe, S., Meyer, T., Wöhl-Bruhn, S.,  Frenzel. Kontakt. Their blueprint is anchored in the immunological memory. 9/1999 - 7/2002 PhD thesis: "Rekombinante Antikörper gegen die NIa-Protease des Plum Pox Virus" (Recombinant antibodies against the NIa protease of the plum pox virus) at the Lehrgebiet Molekulargenetik (now Institut für Pflanzengenetik, Abteilung Pflanzenbiotechnologie), Universität Hannover (now Leibniz Universität Hannover) under the supervision of Prof. Dr. H.-J. Selection of recombinant antibodies from antibody gene libraries. (11) Voedisch, B., Menzel. The antibodies with the best characteristics are then passed on to the Helmholtz Centre for Infection Research (HZI). Antibody Phage Display. Mating antibody phage display with proteomics. Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. Novel human recombinant antibodies against Mycobacterium tuberculosis antigen 85B. The two PhD students Nora Langreder and Kai-Thomas Schneider work on the CORAT consortium. Jacobsen and Dr. Thomas Reinard. Oligopeptide M13 Phage Display in Pathogen Research. In cooperation with partners from research institutes, university hospitals and companies, the team is looking for ways and means to shorten these processes and still comply with all necessary safety and quality requirements for drugs. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to known RBD mutations. (71) Jäger, V.,  Büssow, K., Wagner, A., Weber, S., Hust, M., Frenzel, A. and Schirrmann, T. (2013). September 2019, die Norden Vaccines GmbH gegründet. (90) Wirsing, L., Klawonn, F., Sassen, W., Lünsdorf, H., Probst, C., Hust, M., Mendel, R., Kruse, T. and Jänsch, L. (2015). - identification of disease related biomarkers (immunogenic oligopeptides) using phage display, - develoment of an anti-tick vaccine (GO-Bio8 project) (Info Video). In addition, the team has also created such libraries from the blood of cured corona patients because the probability of finding a suitable antibody is even greater in such cases. A One-Step Process for the Construction of Phage Display scFv and VHH Libraries. (112) Schmitt, L.C., Rau, A., Seifert, O., Honer, J., Schmid, S., Hutt, M., Zantow, J., Hust, M., Dübel, S., Olayioye, M.A. Generation of recombinant antibodies against toxins and viruses by phage display for Diagnostics and Therapy. The production of a genus specific recombinant antibody (scFv) using a recombinant Potyvirus protease. Vom Hiwi-Job bis zur Professur: Hier finden Sie unsere Stellenangebote und unser Profil als Arbeitgeberin. Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile. (106) Derman, Y., Selby, K., Miethe, S., Frenzel, A., Liu, Y., Rasetti-Escargueil, C., Avril, A., Pelat, T., Urbain, R., Fontayne, A., Thullier, P., Sesardic, D., Lindström, M., Hust, M. and Korkeala, H. (2016). (111) Froude, J.W., Pelat, T., Miethe, S., Zak, S.E., Wec, A.Z., Chandran, K., Brannan, J.M., Bakken, R.R., Hust, M., Thullier, P. and Dye, J.M. (15) Soltes, G., Hust, M., Ng, K.K.Y., Bansal, A., Field, J., Stewart, D.I.H., Dübel, S., Cha, S. and Wiersma, E. (2007). (133) Kopertekh, L., Meyer, T., Freyer, C. and Hust M. (2019). (68) Bertz, A., Wöhl-Bruhn, S., Miethe, S., Tiersch, B., Koetz, J., Hust, M., Bunjes, H. and Menzel, H. (2013). and von Nickisch-Rosenegk, M. (2016). The CORAT consortium was initiated by Professor Stefan Dübel and Professor Michael Hust from the Institute for Biochemistry, Biotechnology and Bioinformatics at the TU Braunschweig together with Professor Gundram Jung from the University of Tübingen. Diese Probe aufs Exempel, müssen dann Andere machen, denn Husts Labor an der TU fehlt die nötige Sicherheitsstufe, um mit dem hochinfektiösen Virus „SARS-CoV-2“ zu experimentieren. Phage display, Ed: Lim, T.S. (18) Schirrmann, T., Hust, M., Konthur, Z., Frank, R., Toleikis, L. and Dübel, S. (2007). In: Handbook of therapeutic antibodies, Ed. (2018). In: Antibody engineering, Ed: Kontermann, R. and Dübel, S.. (40) Mersmann, M., Meier, D., Mersmann, J., Helmsing, S., Nilsson, P., Gräslund S.,  Structural Genomics Consortium, Colwill, K., Hust, M. and Dübel, S. (2010). They were obtained from human blood in pre-Corona times and, put simply, contain the information for the basic construction of practically all antibodies that the human species can produce,” explains Kai-Thomas Schneider. Even supposedly minor tasks such as ordering materials or sterilizing work equipment are important for research to function. Vertical migration behaviour of diatom assemblages of Wadden Sea sediments (Dangast/Germany): A study using Cryo-scanning electron microscopy. (139) Wenzel, E.V., Bosnak, M., Tierney, R., Schubert, M., Brown, J., Dübel, S., Efstratiou, A., Sesardic, D., Sticking, P. and Hust, M. (2020). “This is a method of producing antibodies in the test tube without the immunisation of animals,” explains Stefan Dübel, one of the inventors of the method. Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B. Picture credits: Michael Hust/TU Braunschweig. (2016). (95) Tomszak, F., Weber, S., Zantow, J., Schirrmann, T., Hust, M. and Frenzel, A. Ihr Ziel ist es, einen universellen Impfstoff gegen von Zecken übertragene Krankheiten zu entwickeln. Towards "proteome scale" antibody selections using phage display. (140) Sellmann, C., Pekar, L., Bauer, C., Ciesielski, E., Krah, S., Becker, S., Toleikis, L., Kügler, J., Frenzel, A., Valldorf,. Production of Single Chain Fragment Variable (scFv) Antibodies in Escherichia coli Using the LEX Bioreactor. Michael Hust weiß, wovon er redet, wenn er über die Borreliose spricht. An der TU Braunschweig werden – im Gegensatz zu den bisher meist in Tieren erzeugten Antiseren – rein menschliche Antikörper mithilfe der Antikörperphagendisplay-Technologie entwickelt. (55) Hust, M., Meyer, T., Voedisch, B., Rülker, T., Thie, H., El-Ghezal, A., Kirsch, M.I., Schütte, M., Helmsing, S., Meier, D., Schirrmann, T. and Dübel, S. (2011). More than 30 scientists and doctors from academic institutions and industry are now involved in the consortium. A methodological approach to investigate steady state fucoxanthin chlorophyll a/c binding protein mRNA levels in Wadden Sea sediments. Kai-Thomas Schneider adds: “We have all learned a lot and have grown together as a team. The work in the laboratory only works because everyone helps. Phage display for the generation of antibodies for proteome research, diagnostics and therapy. Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity. (128) Beer, L.A., Tatge, H., Schneider, C., Ruschig, M., Hust, M., Barton, J., Thiemann, S., Fühner, V., Russo, G. and Gerhard, R. (2018). Institute of Biochemistry, Biotechnology and Bioinformatics (2018). (2013). V., Ruschig, M., Heine, P.A., Rand, U., Klünemann, T., Meier, D., Langreder, N., Steinke, S., Ballmann, R., Schneider, K.-T., Roth, K.D.R., Kuhn, P., Riese, P., Schäckermann, D., Korn, J., Koch, A., Zock-Emmenthal, S., Becker, M., Scholz, M., Moreira, G.M.S.G., Wenzel, E.V., Russo, G., Garritsen, H.S.P., Casu, S., Gerstner, A., Roth, G., Hermann, A., Schirrmann, T., Dübel, S., Frenzel, A., Van den Heuvel, J., Čičin-Šain, L., Schubert, M. and Hust, M. (2020). (74) Frenzel, A., Kügler, J., Wilke, S., Schirrmann, T. and Hust, M. (2014). “These blueprints show the typical sequence of amino acids that determine how particular antibodies look. (20) Hust, M., Dübel, S. and Schirrmann, T. (2007). Nature Methods 8, 551-558, (6) Hust, M. and Dübel, S. (2005). Dr. Hust specializes in building antibody gene libraries and … (107) Zantow, J., Just, S., Lagkouvardos, I., Kisling, S., Dübel, S., Lepage, P., Clavel, T. and Hust, M. (2016). 5/2011 Habilitation (professorial dissertation, venia legendi for biotechnology), appointed as Privatdozent (PD). Rise and fall of an anti-MUC1 specific antibody. Funktionales Proteom-Display zur Identifikation von Biomarkern. (2018). Identification of an epitope in the membrane proximal external region of gp41 targeted by neutralizing antibodies in plasma from an elite controller using an Env-tailored phage display library. 1 Job ist im Profil von Wolfgang Niemeier aufgelistet. ➜ Research Centers: The research profile of the TU Braunschweig is characterized by several interdisciplinary and cross-faculty research networks, which are organized as centers. Die Grundlage für ihre Arbeit sind die neutralisierenden Antikörper gegen Covid-19, die die Technische Universität Braunschweig gemeinsam mit dem Biotechnologieunternehmen Yumab GmbH im Corat Konsortium entwickelt hat. Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz. AntiBotABE, CDiff, DATMAB, HANTOX, ATAC (Antibody Therapy against Corona) and CORAT. (50) Bourbeillon, J., Orchard, S., Benhar, I., Borrebaeck, C., de Daruvar, A., Dübel, S., Frank, R., Gibson, F., Gloriam, D., Haslam, N., Hiltker, T., Humphrey-Smith, I., Hust, M., Juncker, D., Koegl, M., Konthur, Z., Korn, B., Krobitsch, S., Muyldermans, S., Nygren, P.-A., Palcy, S., Polic, B., Rodriguez, H., Sawyer, A., Schlapshy, M., Snyder, M.,Stoevesandt, O., Taussig, M.J., Templin, M., Uhlen, M., van der Maarel, S., Wingren, C., Hermjakob, H. and Sherman, D. (2010). Production of single chain Fab (scFab) in Bacillus megaterium. (130) Fühner, V., Heine, P.A., Helmsing, S., Goy, S., Heidepriem, J., Loeffler, F.F., Dübel, S., Gerhard, R. and Hust, M. (2018). (79) Trott, M., Weiß, S., Antoni, S., Koch, J., von Briesen, H., Hust, M. and Dietrich, U. Once our project was designed, we sought advice from specialists in the field. Human antibody gene libraries. The consortium develops neutralizing antibodies against the SARS-CoV-2 virus. Generation and analysis of the improved human HAL9/10 antibody phage display libraries. Email: m.hust@tu-braunschweig.de "Wir im Norden ‚können‘ weltweit ausstrahlende Biotech-Hochtechnologie - das möchten wir auch mit dem Namen ausdrücken", kommentierte Mitgründer Professor Michael Hust von der TU Braunschweig. Development of human and macaque antibodies using antibody phage display for the detection of equine encephalitis viruses. Curriculum vitae 10/1993 - 7/1999 Studies of Biology at the Carl-von-Ossietzky Universität, Oldenburg. : 0531 391-5760 E-Mail: m.hust@tu-braunschweig.de Selection Strategies II: Antibody phage display. Construction of human naive antibody gene libraries. (7) Schirrmann, T., Hust, M. und Dübel, S. (2005). Journal of Microbiological Methods 38, 69-80, (1) Janssen, M., Hust, M., Rhiel, E. and Krumbein, W.E. (25) Schirrmann, T., Al-Halabi, L., Dübel, S. and Hust, M. (2008). Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. (98) Blokzijl, A., Zieba, A., Hust, M., Schirrmann, T., Helmsing, S., Grannas, K., Hertz, E., Moren, A., Chen, L., Soderberg, O., Moustakas, A., Dübel, S. and Landegren, U. Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. Epitope Mapping by Phage Display. (137) Jakob, V., Helmsing, S., Hust, M. and Empting, M. (2020). ➜ There are four core research areas at TU Braunschweig: Future City, Metrology, Mobility and Infections and Therapeutics. An der TU Braunschweig können solche Antikörper gentechnologisch komplett im Reagenzglas gewonnen werden. Michael Hust | Metropolregion Hannover-Braunschweig-Göttingen-Wolfsburg | Professor für Biotechnologie bei Technische Universität Braunschweig | 415 Kontakte | Vollständiges Profil von Michael auf LinkedIn anzeigen und vernetzen Human Monoclonal Antibodies: Methods and Protocols, Ed: Steinitz, M.. (73) Kügler, J., Zantow, J., Meyer, T., and Hust, M. (2013). ORFeome Phage Display. They then test for inhibition, i.e. Persistence of SARS-CoV-2 specific B-and T-cell responses in convalescent COVID-19 patients6-8 months after the infection. “At first we don’t test with the real corona virus, but only with part of the virus’ surface. (47) Naseem, S., Meens, J., Jores, J., Heller, M., Dübel, S., Hust, M. and Gerlach, G.F. (2010). Gene Function Analysis, Ed: Ochs, M.F.. (76) Miethe, S., Rasetti-Escargueil, C., Liu, Y., Chahboun, S., Pelat, T., Avril, A., Frenzel, A., Schirrmann, T., Thullier, P., Sesardic, D. and Hust, M. (2014). C., Jordan, E., El-Ghezal, A., Schirrmann, T., Hust, M. und Jostock, T. (2005). Research group leader Room: 106 Phone: +49.531.391.5760 Fax: +49.531.391.5763 e-mail: m.hust@tu-bs.de. Here, more than twenty antibody candidates have already been identified which neutralise the novel SARS-CoV-2 virus. Identification of immunogenic proteins and generation of antibodies against Salmonella Typhimurium using phage display. Dübel, S. and Reichert, J.M.. (82) Stech, M., Hust, M., Schulze, C., Dübel, S. and Kubick, S. (2014). A gene library of this kind comprises around 10 billion antibody blueprints. Generation and characterization of protective antibodies to Marburg virus. Bacterial flagellar capping proteins adopt diverse oligomeric states. Das Corat wurde von Stefan Dübel und Michael Hust (TU Braunschweig) zusammen mit Gundram Jung (Universität Tübingen) initiiert und ist mittlerweile auf ein Konsortium von 40 Wissenschaftlern und Ärzten aus akademischen Institutionen und der Industrie … To support the CORAT consortium they have temporarily put their own projects on hold. Die Antikörperfabrik: Antikörper für jedes Protein. (99) Rohrbeck, A., Fühner, V., Schröder, A., Hagemann, S., Vu, X.-H., Berndt, S., Hust, M., Pich, A. and Just, I. Sehen Sie sich das Profil von Wolfgang Niemeier auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. (61) Zhang, C., Helmsing, S., Zagrebelsky, M., Schirrmann, T., Marschall, A.L.J., Schüngel, M., Korte, M., Hust, M. and Dübel, S. (2012). Immunotherapy of Cancer: Methods and Protocols, Ed. Designing human antibodies by phage display. Antibody production by the Gram-positive bacterium Bacillus megaterium. Auszeichnungen für Corona-Antikörperforschung an der TU Braunschweig. Generation of recombinant antibodies for human tissue kallikrein 7 to address skin diseases. (2016). Oligomeric forms of single chain immunoglobulin (scIgG). The influence of antibody fragment format on phage display based affinity maturation of IgG. Epitope Mapping via Phage Display from single gene libraries. In cooperation with the biotechnology company YUMAB, a spin-off of the TU Braunschweig, the Carolo-Wilhelmina researchers have investigated several thousand antibodies. (64) Meyer, T.,  Schirrmann, T., Frenzel, A., Miethe, S., Stratmann-Selke, J., Gerlach, G.F., Strutzberg-Minder, K., Dübel, S., and Hust, M. (2012). Lecturer for molecular biotechnology. Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. 12/2014 Appointed as professor for biotechnology (außerplanmäßiger Professor). (136) Tenspolde, M., Zimmermann, K., Weber, L.C., Hapke, M., Lieber, M., Dywicki, J., Frenzel, A., Hust, M., Galla, M., Buitrago-Molina, L.E., Manns, M.P., Jaeckel, E. and Hardtke-Wolenski, M. (2019). Phage display, Ed: Lim, T.S. Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail. The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. They are part of the CORAT consortium that is developing a passive immunotherapy against the corona virus. Entwicklung von therapeutischen Antikörpern im Reagenzglas. Schlüsselreagenzien für den nächsten großen Schritt. and Rhiel, E. (1999). A human scFv antibody generation pipeline for proteome research. Structural differences of amyloid-β fibrils revealed by antibodies from phage display. Braunschweig. (9) Voedisch, B., Menzel. E.,  Condemine, F., Bottex, C., Vidal, D., Lefranc, M.P., Dübel, S. and Thullier, P. (2007). (2021). (22) Schirrmann, T., Hust, M. and Dübel, S. (2007). Improving phage display throughput by using Hyperphage, miniaturized titration and pVIII (g8p) ELISA. TU Braunschweig is involved in the “PhoenixD” cluster at Leibniz Universität Hannover (LUH), which is researching new optical technologies. Die Daten dienen dazu, das Webangebot zu optimieren.Weitere Informationen finden Sie in unserer Datenschutzerklärung. Michael Hust studierte von 1993 bis 1999 Biologie an der Carl von Ossietzky Universität Oldenburg . The two have been pursuing their doctorate at the Institute for Biochemistry, Biotechnology and Bioinformatics for about a year. The research of the TU scientists in the consortium contributes to the research focus “Infection and Therapeutics” at the TU Braunschweig. In the interview they told us about the search for antibodies at Carolo-Wilhelmina, what antibody libraries are and why teamwork is so important for their research. Human antibodies neutralizing diphtheria toxin in vitro and in vivo. Influence of the hydromechanical stress and temperature on growth and antibody fragment production with Bacillus megaterium. (13) Hust, M., Meysing, M, Schirrmann, T., Selke, M., Meens, J., Gerlach, G.-F. and Dübel, S. (2006). (2011). (104) Mendonça, M., Moreira, G.M., Conceição, F.R., Hust, M., Mendonça, K.S., Moreira, Â.N., França, R.C., da Silva, W.P., Bhunia, A.K. Website: https://www.tu-braunschweig.de/bbt/biotech/corat-corona-antibody-team. (147) Sherina, N., Piralla, A., Du, L., Wan, H., Kumagai-Braesh, M., Andréll, J., Braesch-Andersen, S., Cassaniti, I., Percivalle, E., Sarasini, A., Bergami, F., Di Martino, R., Colaneri, M., Vecchia, M., Sambo, M., Zuccaro, V., Bruno, R., Oggionni, T., Meloni, F., Abolhassani, H., Bertoglio, F., Schubert, M., Byrne-Steele, M., Han, J., Hust, M., Xue, Y., Hammarström, L., Baldanti, F., Marcotte, H. and Pan-Hammarström, Q. The consortium scientists are confident that they will also be able to find a suitable candidate against the corona virus. and Hust, M.. (116) Frenzel, A., Kügler, J., Helmsing, S., Meier, D., Schirrmann, T., Hust, M. and Dübel, S. (2017). (86) Froude, J.W., Pelat, T., Miethe, S., Zak, S., Bakken, R., Hust, M., Thullier, P. and Dye, J.M. Lecturer for molecular biotechnology. (60) David, F., Steinwand, M., Hust, M., Bohle, K., Ross, A., Dübel, S. and Franco-Lara, E. (2011). (72) Frenzel, A., Hust, M. and Schirrmann, T. (2013). (34) Pelat, T., Hust, M., Hale, M., Lefranc, M.-P., Dübel, S. and Thullier, P. (2009). Wissenschaftler aus Braunschweig haben am 11. Yotnda, P.. (48) Dübel, S., Stoevesandt, O., Taussig, M.J. and Hust, M. (2010). Analysis of single chain antibody sequences using the VBASE2 Fab Analysis Tool.